產品名稱：Angiopoietin-like 4 human ELISA
產    地：Demeditec 
產品貨號：JP27749
產品規格：96 Tests
產品說明：
Special remarks:
INTRODUCTION
Angiopoetin-like  4  (ANGPTL4)  is  a  member  of  the  angiopoietin/ANGPTL  family. Human ANGPTL4 consists of 406 amino acids. Its protein structure is common to the angiopoietins, with a signal peptide directing secretion, an N-terminal coiled-coil domain (CCD), a linker, and a C-terminal fibrinogen-like domain (FLD). Full-length ANGPTL4  is  secreted  by  liver  and  adipose  tissues  and  cleaved  to  generate circulating  CCD  and  FLD  fragments.  ANGPTL4  plays  important  roles  in  lipid  and glucose  metabolism.  It  inhibits  lipoprotein  lipase  (LPL)  activity  by  breaking  the dimmer molecule, and elevates plasma TG level. Meanwhile, it is also implicated in breast cancer metastasis to lung via the regulation of vascular integrity.
Both  of  two  antibodies  used  in  this  ELISA  kit  recognize  the  N-terminal  portion  of human ANGPTL4 respectively.
PRINCIPLE
This kit is a solid phase sandwich ELISA using 2 kinds of highly specific antibodies. Tetra  Methyl  Benzidine  (TMB)  is  used  as  a  coloring  agent  (Chromogen).  The strength of coloring is proportional to the quantities of Human ANGPTL4.
INTENDED USE
This kit is capable for the quantitative determination human ANGPTL4 in serum and EDTA-plasma. In  the  case  of  normal  individuals,  many  of  blood  samples  will  fall  below  the sensitivity. When cell culture media is measured, some suitable arrangements are required (for  example,  negative  media  control)  since  some  FBS  (FCS)  will  be  measured high level ANGPTL4 with this kit.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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